Clauser et al. studied the effect of Lecicarbon suppositories versus placebo. This trial was performed, in part, to show how double-blind studies could be used to differentiate between placebo and active effects.
They found that in a double-blind clinical trial, Lecicarbon was effective in 66% of 134 patients compared with success in 10% of 48 patients in the placebo group.
One conclusion they drew on Lecicarbon was that Lecicarbon “supports a normal, daily reflex bowel pattern in a natural way through carbon dioxide production.”2